
Methodological concerns and interpretative limitations of assessing subjective effects of ketamine
A new commentary published in npj Mental Health Research raises questions about a widely cited meta-analysis comparing ketamine and psilocybin therapy. Author Ramūnas Janavičius points

Ketamine Has a Hidden Effect on The Brain Researchers Have Been Missing For Decades
New research from Washington University School of Medicine (led by pharmacologist Tao Che) found that ketamine directly binds to and activates opioid receptors, not just

Episode #22 How Ketamine is Rewriting the Biology of Depression
What if the traditional view of depression—a simple imbalance of serotonin—was wrong? In this episode of Learning and Living STEMM in Connecticut, host Tanimu Deleon

Norway Becomes the First Country to Publicly Fund Generic Ketamine for Depression
In the year 2000, psychiatry experienced one of the most important breakthroughs in decades: researchers showed that ketamine, a widely used anesthetic, could produce a

Learn how ketamine therapy may help with depression, anxiety, and PTSD when other treatments haven’t worked.
May is Mental Health Awareness Month — a time to open up conversations we often keep quiet. If you or someone you love has been

Neuroscience of Depression and Ketamine
This article examines the evolving understanding of depression and the mechanisms behind ketamine’s antidepressant effects. It discusses the shift away from the traditional “chemical imbalance”

Ketamine vs. Esketamine: What New Research Means for Depression Treatment
A recent study published on PubMed highlights promising findings in the treatment of depression using intranasal ketamine. Researchers found that racemic ketamine is non-inferior to

Mindbloom Faces Wrongful Death Lawsuit Over At-Home Ketamine Overdose
Telehealth ketamine therapy provider Mindbloom is facing a wrongful-death lawsuit after a 27-year-old male patient died from ketamine toxicity in October 2023, allegedly while under

Ketamine Holds Promise for Cognitive Benefits, Study Shows
For over 50 years, ketamine has been known as a safe anesthetic, and at lower doses, an effective treatment for depression. Emerging research suggests it

Intravenous Ketamine Outperforms Intranasal Esketamine in Depression
A retrospective study of 153 patients with severe treatment-resistant depression found that twice-weekly IV ketamine over 4–5 weeks led to faster and greater symptom reduction

Cleveland Clinic study shows ketamine infusions effective for chronic pain patients
A four-year Cleveland Clinic study of 1,034 patients found that low-dose ketamine infusions significantly improved pain, sleep, and daily function for 20%–46% of people with

Ketamine Safe, Effective For Chronic Pain
A Cleveland Clinic study found that low-dose IV ketamine infusions are safe and effective for chronic pain management. Among more than 1,000 patients, 20%–46% saw

Ketamine for Suicidality: Evidence on Rapid Effects, Mechanisms, and Clinical Considerations
Ketamine has emerged as a promising treatment for suicidal ideation (SI) in patients with major depressive disorder (MDD), showing rapid and sustained reductions in suicidality.

Ketamine Reduces Suicidality-Associated ED Use in Treatment-Resistant Depression
A new Journal of Clinical Psychiatry study from the Mayo Clinic found that ketamine and esketamine treatment can significantly reduce emergency department visits related to

Real-World Effectiveness of Maintenance Ketamine Infusions for Treatment-Resistant Depression in Major Depressive Disorder and Bipolar Disorder
This study followed 135 patients with severe depression—110 with treatment-resistant major depressive disorder (TRD) and 25 with treatment-resistant bipolar depression (TRBD)—who had already responded to
