A Cleveland Clinic study found that low-dose IV ketamine infusions are safe and effective for chronic pain management. Among more than 1,000 patients, 20%–46% saw lasting improvements in pain, physical function, and sleep for at least six months, with minimal side effects. Nearly half reported reduced pain-related anxiety, and 80% returned for additional treatments. Researchers say ketamine offers a promising, non-opioid option for patients with chronic pain who have exhausted other therapies.