Ketamine and Esketamine in Acute Suicidal Presentations

Ketamine is getting attention for how fast it can work, sometimes within hours. A new review in Neuropsychiatric Disease and Treatment looks at what the research supports for people in a suicidal crisis. IV ketamine may ease suicidal thoughts in the short term for some adults. The authors stress that it works best as one part of ongoing care, including safety planning and follow-up support.

Source: Słupska A, et al. “Ketamine and Esketamine in Acute Suicidal Presentations: Evidence, Limits, and a Conceptual Recovery-Enabling Downstaging Framework.” Neuropsychiatric Disease and Treatment, 2026;22:641718. doi.org/10.2147/NDT.S641718