A four-year Cleveland Clinic study of 1,034 patients found that low-dose ketamine infusions significantly improved pain, sleep, and daily function for 20%–46% of people with chronic pain, with benefits lasting up to six months. Nearly half reported reduced pain-related anxiety, and 80% returned for repeat treatments. The therapy was safe, with rare side effects. Researchers say ketamine offers a promising, non-opioid option for chronic pain management and may pave the way for future FDA approval.